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The term “ether” as used herein is represented by the formula A 1OA 2, where A 1 and A 2 can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

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When a compound as disclosed herein is used contemporaneously with one or more other drugs, a pharmaceutical composition containing such other drugs in addition to the compound disclosed herein may be utilized, but is not required.

Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.

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The term "cyclic group" is used herein to refer to either aryl groups, non-aryl groups (i.

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For example, in one formulation, the CNS active agent has a time to maximum concentration (Tmax) and the mechanoreceptor stimulator has a Tmax, the delay in the release of mechanoreceptor stimulator is equal to the Tmax of the CNS active agent minus the Tmax of the mechanoreceptor stimulator plus about 5 to about 30 minutes, more preferably plus about 10 to 20 minutes.

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Sedation-related effects” are side effects of the compound (when therapeutic effect is tranquilizing, anexielytic, analgetic, spasmolytic, neuroprotective, etc.

The term "sulfoxide" as used herein is represented by the formula A1S(O)A2, where Al and AZ can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

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These conditions permit vagal afferent activation of the gastric milieu by the vagal neuromodulator concurrently with the achievement of a pharmacological “effective” CNS agent plasma concentration.

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The materials, compounds, compositions, articles, and methods described herein may be understood more readily by reference to the following detailed description of specific aspects of the disclosed subject matter and the Examples included therein.

Furthermore, zonisamide is approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.

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In this embodiment, the delay in the administration or release of mechanoreceptor stimulator is typically equal to the Tmax of the CNS active agent minus the Tmax of the mechanoreceptor stimulator plus about 5 to about 30 minutes.

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More serious and rare adverse reactions such as an increased risk of stroke and ministroke; neuroleptic malignant syndrome (NMS) which symptoms include fever, rigid muscles, confusion; tardive dyskinesia (TD) which symptoms include uncontrolled and abnormal movements of body parts.

For example, the neuromodulator or combination of neuromodulators may be provided in one dosage form and the CNS active agent may be provided in a separate dosage form.

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Having described the formulation of the pharmaceutical composition, the reduced dosages of CNS active agents as part of the pharmaceutical composition of the present invention, are set forth below.

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The United States leads the world in progressive drug improvement, benefiting patients and caregivers around the globe by guaranteeing entry to new cures and coverings for a range of diseases. Over the course of its mandate, the council thought of the affect that intercourse and gender, in addition to different id components similar to age, race and income status, can have on an individual's access to health care and their capability to effectively preserve and enhance their health.
Also, whereas the model assumes that national pharmacare would lead to lower negotiated costs for drugs, we did not think about any modifications in the pharmacy markups and meting out fees. There exist vital differences in pharmacy fees throughout the country, which may make up as much as 30 per cent of the total cost of a drug in some locations. This generally is a complex subject, resulting from different commerce-offs made during negotiations by provincial or territorial governments and pharmacists at different cut-off dates. Whereas the cost modelling done for the council did not factor in any changes to those fees underneath nationwide pharmacare, our hope is that the Canadian drug company will examine these variations in pharmacy fees and balance efficiencies with proper recognition of the important services pharmacists provide Canadians.
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